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Showing 1–2 of 2 results
Advanced filters: Author: Trudy Ramlall Clear advanced filters

  • γδTCRs detect and initiate immune responses to various antigens. Here, Hoque et al. report cryoEM structures of two γδTCRs bound by Fabs, revealing their assembly with CD3 signaling components and clonotype-dependent propensity for dimerization.

    • Mohammed Hoque
    • John Benji Grigg
    • Kei Saotome
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Here, cryo-electron microscopy structures reveal how the chemokine receptor CXCR4 oligomerizes and how it is regulated by its physiological ligand CXCL12, the small-molecule drug AMD3100 and the monoclonal antibody REGN7663.

    • Kei Saotome
    • Luke L. McGoldrick
    • Matthew C. Franklin
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 315-325