Nature Search

Absence of Bile Acids in the Digestive Juice of the Swamp Crayfish (Procanbarus clarkii)

KAZUMI YAMASAKI
TOSHIAKI USUI
SCHUN-ICHI TAKATSUKI
Research27 Mar 1965
Nature

Volume: 205, P: 1326-1327
Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor

Kappa-opioid receptors (KORs) influence pain and itch. Here, using cryoEM, spectroscopy, and cell tests, the authors show how specific amino acids shape KOR responses. These findings may guide development of pain treatments with fewer side effects.

Chiyo Suno-Ikeda
Ryo Nishikawa
Ryoji Suno
ResearchOpen Access28 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Erratum: A plastidial sodium-dependent pyruvate transporter

Tsuyoshi Furumoto
Teppei Yamaguchi
Katsura Izui
Amendments and Corrections28 Sept 2011
Nature

Volume: 478, P: 274
Photocatalytic solar hydrogen production from water on a 100-m² scale

Carbon-neutral hydrogen can be produced through photocatalytic water splitting, as demonstrated here with a 100-m² array of panel reactors that reaches a maximum conversion efficiency of 0.76%.

Hiroshi Nishiyama
Taro Yamada
Kazunari Domen
Research25 Aug 2021
Nature

Volume: 598, P: 304-307
Interaction of daytime and nighttime light exposure on objective sleep quality in patients with bipolar disorder: a cross-sectional analysis of the APPLE cohort

Yuichi Esaki
Kenji Obayashi
Tsuyoshi Kitajima
ResearchOpen Access18 Aug 2025
Translational Psychiatry

Volume: 15, P: 1-6
Grease matrix as a versatile carrier of proteins for serial crystallography

Serial femtosecond crystallography experiments with diverse protein microcrystal suspensions are facilitated using a grease matrix as a carrier medium for sample injection.

Michihiro Sugahara
Eiichi Mizohata
So Iwata
Research10 Nov 2014
Nature Methods

Volume: 12, P: 61-63
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese

Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060.

Ikuyo Kou
Nao Otomo
Shiro Ikegawa
ResearchOpen Access15 Aug 2019
Nature Communications

Volume: 10, P: 1-9
Comparative study of ERP habituation to tones and fearful vocalizations in autism spectrum disorders: a translational biomarker for sensory hypersensitivity

Kohei Shimono
Natsuko Kashida
Manabu Makinodan
ResearchOpen Access05 Nov 2025
Molecular Psychiatry

P: 1-9
Physiological and pathological clinical conditions and light scattering in brain

Tsuyoshi Kurata
Sachiko Iwata
Osuke Iwata
ResearchOpen Access11 Aug 2016
Scientific Reports

Volume: 6, P: 1-7
Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion

Takumi Shiraishi
Shogo Inui
Osamu Ukimura
ResearchOpen Access13 Oct 2020
Scientific Reports

Volume: 10, P: 1-8
Aggressive periodontitis and NOD2 variants

Noriyoshi Mizuno
Kodai Kume
Hidemi Kurihara
Research19 May 2020
Journal of Human Genetics

Volume: 65, P: 841-846
Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population

Hisatsugu Koshimizu
Shun Nogawa
Tsuyoshi Miyakawa
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-8
Mechanical Properties of Poly(L-Lactide) Films Controlled by Blending with Polyesters of Lignin-Derived Stable Metabolic Intermediate, 2-Pyrone-4,6-Dicarboxylic Acid (PDC)

Tsuyoshi Michinobu
Masami Bito
Kiyotaka Shigehara
Research05 Aug 2009
Polymer Journal

Volume: 41, P: 843-848
Fusible, Elastic, and Biodegradable Polyesters of 2-Pyrone-4,6-Dicarboxylic Acid (PDC)

Tsuyoshi Michinobu
Masami Bito
Kiyotaka Shigehara
Research09 Oct 2009
Polymer Journal

Volume: 41, P: 1111-1116
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Yoichiro Kamatani and colleagues perform a genome-wide association study (GWAS) for body mass index using data from 173,430 Japanese individuals. They find 85 significant loci, 51 of which are novel, and use trans-ancestral meta-analysis of GWAS from European samples to identify 61 additional new loci.

Masato Akiyama
Yukinori Okada
Yoichiro Kamatani
Research11 Sept 2017
Nature Genetics

Volume: 49, P: 1458-1467
Foetal growth, birth transition, enteral nutrition and brain light scattering

Osuke Iwata
Sachiko Iwata
Shiji Saitoh
ResearchOpen Access29 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
A plastidial sodium-dependent pyruvate transporter

Tsuyoshi Furumoto
Teppei Yamaguchi
Katsura Izui
Research24 Aug 2011
Nature

Volume: 476, P: 472-475
Direct metabolomics for plant cells by live single-cell mass spectrometry

Single-cell analysis has shown that a lot of information can be lost by analyzing homogenates of tissues. This protocol describes how to remove the contents of a single plant cell and directly analyze the metabolites by mass spectrometry.

Takashi Fujii
Shuichi Matsuda
Tsutomu Masujima
Protocols27 Aug 2015
Nature Protocols

Volume: 10, P: 1445-1456
Rain-induced bioecological resuspension of radiocaesium in a polluted forest in Japan

Kazuyuki Kita
Yasuhito Igarashi
Yuichi Onda
ResearchOpen Access18 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography

Tsuyoshi Nishiguchi
Kyosuke Yamanishi
Gen Shinozaki
ResearchOpen Access03 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-9
Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

Taro Kishi
Tomoko Tsunoka
Nakao Iwata
Research04 Sept 2009
Journal of Human Genetics

Volume: 54, P: 629-633
Positive Association of the Serotonin 5-HT₇ Receptor Gene with Schizophrenia in a Japanese Population

Masashi Ikeda
Nakao Iwata
Norio Ozaki
Research28 Sept 2005
Neuropsychopharmacology

Volume: 31, P: 866-871
Sema3A regulates bone-mass accrual through sensory innervations

Sema3A, a member of the semaphorin family of proteins, is shown to regulate bone remodelling indirectly by modulating sensory nerve development in mice.

Toru Fukuda
Shu Takeda
Hiroshi Itoh
Research05 May 2013
Nature

Volume: 497, P: 490-493
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

Takehiko Yamanashi
Masaaki Iwata
Koichi Kaneko
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-11
Epigenetic signals associated with delirium replicated across four independent cohorts

Yoshitaka Nishizawa
Kaitlyn C. Thompson
Gen Shinozaki
ResearchOpen Access04 Jul 2024
Translational Psychiatry

Volume: 14, P: 1-7
Association between circadian activity rhythms and mood episode relapse in bipolar disorder: a 12-month prospective cohort study

Yuichi Esaki
Kenji Obayashi
Tsuyoshi Kitajima
ResearchOpen Access13 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-8
Neural correlates of tactile simultaneity judgement: a functional magnetic resonance imaging study

Takahiro Kimura
Hiroshi Kadota
Makoto Miyazaki
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
Compound heterozygous splice site variants in the SCLT1 gene highlight an additional candidate locus for Senior-Løken syndrome

Satoshi Katagiri
Takaaki Hayashi
Tadashi Nakano
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

Hiroki Takeuchi
Keiko Imamura
Haruhisa Inoue
ResearchOpen Access25 Mar 2020
npj Vaccines

Volume: 5, P: 1-11
Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis

Katsuyoshi Tomomatsu
Hirotaka Yasuba
Koichiro Asano
ResearchOpen Access04 Apr 2023
Scientific Reports

Volume: 13, P: 1-8
Meniscus surface texture is associated with degenerative changes in biological and biomechanical properties

Shunya Otani
Takashi Kanamoto
Ken Nakata
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration

Wen Shi
Takashi Kanamoto
Ken Nakata
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Integrin α2β1 plays an important role in the interaction between human articular cartilage-derived chondrocytes and atelocollagen gel

Takashi Kanamoto
Minami Hikida
Ken Nakata
ResearchOpen Access19 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

Bora Gurel
Tsuyoshi Iwata
Angelo M De Marzo
Research20 Jun 2008
Modern Pathology

Volume: 21, P: 1156-1167
Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia

Tamara L Lotan
Berrak Gumuskaya
Angelo M De Marzo
Research07 Dec 2012
Modern Pathology

Volume: 26, P: 587-603

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