Hydrogels have attracted considerable attention in the biomedical applications because of their high functionalities, biocompatibility and biodegradability. This study on the novel hyaluronic acid (HA) nanogel-based hydrogel comprising HA modified with cholesterol derivatives and maleimide crosslinking groups. Depending on the degree of cholesterol derivative substitution, the properties such as water uptake, gelation behavior and protein encapsulation was investigated. The results suggested that the hydrogels enhanced peptide and protein trapping abilities have potential as a new hyaluronan hydrogel for biomedical applications.
- Kohei Yabuuchi
- Toru Katsumata
- Akio Kishida
