In this study, the authors show that chromatin of Hox genes is arranged in discrete domains. Patterning signals trigger recruitment of transcription factors to these domains, leading to rapid clearance of repressive histone methylation. This provides further insight into the transcriptional mechanisms underlying the establishment of epigenetically inherited rostrocaudal neuronal identity.
- Esteban O Mazzoni
- Shaun Mahony
- Hynek Wichterle
