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Showing 1–2 of 2 results
Advanced filters: Author: Tyler H. Stanage Clear advanced filters

  • Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death.

    • Tyler H. Stanage
    • Shudong Li
    • Simon J. Boulton
    ResearchOpen Access
    Nature Cell Biology
    P: 1-15

  • EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR), but its role in DDR-deficient cancers remains unclear. Here, the authors find EXO1 loss as synthetic lethal with many DDR genes involved in various cancers, including genes from Fanconi Anaemia pathway, BRCA1-A complex, and spliceosome factor ZRSR2; such interactions represent potential clinical targets.

    • Marija Maric
    • Sandra Segura-Bayona
    • Simon J. Boulton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18