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Showing 101–108 of 108 results
Advanced filters: Author: Tyler Jacks Clear advanced filters

  • Desmosomes are adhesion complexes that are related to adherens junctions, and recent studies using mouse genetic approaches have uncovered a role for desmosomes in tumour suppression.

    • Rachel L. Dusek
    • Laura D. Attardi
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 317-323

  • The human tumour suppressor LKB1 directly phosphorylates and activates AMPK, a central metabolic sensor. AMPK is a key therapeutic target in patients with diabetes, and the connection between AMPK and several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants investigation in patients with cancer.

    • David B. Shackelford
    • Reuben J. Shaw
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 563-575

  • More than half of all patients with cancer receive radiation therapy, but normal tissue tolerance to radiation often limits the ability to cure tumours with radiation therapy. Here, Moding, Kastan and Kirsch discuss current approaches and possible future directions for combining radiation therapy with targeted therapies to enhance the probability of tumour cure.

    • Everett J. Moding
    • Michael B. Kastan
    • David G. Kirsch
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 526-542

  • There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour suppression has remained challenging. As new roles for p53 emerge, this Opinion dissects the role of p53 in tumour suppression.

    • Kathryn T. Bieging
    • Stephano Spano Mello
    • Laura D. Attardi
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 359-370