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Showing 1–10 of 10 results
Advanced filters: Author: Tyler Walther Clear advanced filters

  • Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

    • Ferdinandos Skoulidis
    • Haniel A. Araujo
    • John V. Heymach
    ResearchOpen Access
    Nature
    Volume: 635, P: 462-471

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Human proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce viral infectivity. Here, the authors show that SERINC3 has architecture resembling non-ATP dependent lipid transporters and induces loss of membrane asymmetry correlated with changes in envelope conformation and loss of infectivity.

    • Susan A. Leonhardt
    • Michael D. Purdy
    • Mark Yeager
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • A new approach is used to target BET family bromodomains which are found in transcriptional regulators where they mediate the recognition of acetyl-lysine chromatin marks. Structural data reveal how the compound JQ1 binds to the bromodomain of BRD4. BRD4 has been implicated in a subtype of human squamous carcinomas, and JQ1 is found to inhibit the growth of BRD4 dependent tumours in mouse models.

    • Panagis Filippakopoulos
    • Jun Qi
    • James E. Bradner
    Research
    Nature
    Volume: 468, P: 1067-1073

  • Using large-scale single-nucleus transcriptomics, Nicin et al. report insights into human cardiac hypertrophy, caused by pressure overload, at single-cell resolution. The authors show that intercellular communication, particularly via the Eph receptor tyrosine kinase EPHB1, is impaired in human cardiomyopathy.

    • Luka Nicin
    • Sam Michael Schroeter
    • Stefanie Dimmeler
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 174-185

  • The nuclear factor TOX is highly expressed in antigen-specific dysfunctional T cells in tumours and exhausted T cells during chronic viral infection and is a crucial regulator of the differentiation of tumour-specific T cells.

    • Andrew C. Scott
    • Friederike Dündar
    • Andrea Schietinger
    Research
    Nature
    Volume: 571, P: 270-274