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Showing 1–4 of 4 results
Advanced filters: Author: Tzu-Jing Yang Clear advanced filters

  • The fungal SND pathway inserts a wide range of proteins into the ER membrane. Here, SND3 is identified as a membrane insertase within a distinct SEC61 translocon complex, implying a role in co-translational insertion of multipass membrane proteins.

    • Tzu-Jing Yang
    • Saumyak Mukherjee
    • Melanie A. McDowell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Hsu and co-workers integrate cryo-electron tomography, cryo-electron microscopy and mass spectrometry to reveal the structural polymorphism of a pig coronavirus spike protein within intact viral particles, and how glycosylation modulates the conformational changes pertinent to host recognition.

    • Cheng-Yu Huang
    • Piotr Draczkowski
    • Shang-Te Danny Hsu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Cryo-EM structures and functional analyses of the SARS-CoV-2 B.1.1.7 variant spike protein reveal that the A570D mutation creates a molecular switch to regulate up-down conformations of the ACE2 receptor-binding domain through a pedal-bin-like mechanism.

    • Tzu-Jing Yang
    • Pei-Yu Yu
    • Shang-Te Danny Hsu
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 731-739

  • Mass spectrometric profiling of a glycan library reveals that sialylated glycans, especially sialic acid-containing gangliosides, interact with the RBD of the SARS-CoV-2 spike protein and are involved in ACE2-dependent viral infection.

    • Linh Nguyen
    • Kelli A. McCord
    • John S. Klassen
    Research
    Nature Chemical Biology
    Volume: 18, P: 81-90