Nature Search

LDL receptor-GFP fusion proteins: new tools for the characterisation of disease-causing mutations in the LDL receptor gene

Henrik Uffe Holst
Frederik Dagnaes-Hansen
Thomas Gryesten Jensen
Research11 Dec 2001
European Journal of Human Genetics

Volume: 9, P: 815-822
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.

Magdalena Laska
Scott Lowe
Bjørn Nexø
ResearchOpen Access24 Jun 2008
Nature Precedings

P: 1
A second serine protease associated with mannan-binding lectin that activates complement

Steffen Thiel
Thomas Vorup-Jensen
Jens C. Jensenius
Research03 Apr 1997
Nature

Volume: 386, P: 506-510
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic conditions.

Søren T. Skou
Mette Nyberg
Alessio Bricca
ResearchOpen Access30 Jun 2025
Nature Medicine

Volume: 31, P: 3176-3182
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
Correction: Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception

Ya-Chun Chen
Michaela Auer-Grumbach
Jan Senderek
Amendments and Corrections29 Jul 2015
Nature Genetics

Volume: 47, P: 962
The optical afterglow of the short γ-ray burst GRB 050709

Jens Hjorth
Darach Watson
Chryssa Kouveliotou
Research06 Oct 2005
Nature

Volume: 437, P: 859-861
Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Establishing the relative transmissibility of emerging variants of SARS-CoV-2 is key for pandemic management. Here, the authors use full-population administrative data from Denmark linked to PCR test results and estimate that the Alpha variant was ~60% higher than other strains circulating in early 2021.

Frederik Plesner Lyngse
Kåre Mølbak
Carsten Thure Kirkeby
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-8
No supernovae associated with two long-duration γ-ray bursts

GRB 060505 and GRB 060614 were not accompanied by supernova emission down to limits hundreds of times fainter than the archetypal SN 1998bw that accompanied GRB 980425, and fainter than any type Ic supernova ever observed.

Johan P. U. Fynbo
Darach Watson
Marta Zub
Research21 Dec 2006
Nature

Volume: 444, P: 1047-1049
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

Fergus J. Couch
Karoline B. Kuchenbaecker
Antonis C. Antoniou
ResearchOpen Access27 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells

The differentiation of human pluripotent stem cells into dopaminergic neurons is challenging. Here, the authors developed lineage-restricted undifferentiated stem cells, which have an enhanced ability for differentiating into dopaminergic neurons.

Muyesier Maimaitili
Muwan Chen
Mark Denham
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-23
Astrocytic GABA transporter activity modulates excitatory neurotransmission

Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit neural glutamatergic signalling.

Kim Boddum
Thomas P. Jensen
Matthew C. Walker
ResearchOpen Access25 Nov 2016
Nature Communications

Volume: 7, P: 1-10
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 known and 6 new EOC susceptibility loci for association in BRCA1 and BRCA2 mutation carriers.

Karoline B Kuchenbaecker
Susan J Ramus
Georgia Chenevix-Trench
Research12 Jan 2015
Nature Genetics

Volume: 47, P: 164-171
Comparison of temporal artery ultrasound versus biopsy in the diagnosis of giant cell arteritis

Michael Stormly Hansen
Lene Terslev
Steffen Hamann
Research29 Jan 2022
Eye

Volume: 37, P: 344-349
High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

A high proportion of confirmed SARS-CoV-2 cases in Denmark were sequenced during the pandemic and linked to demographic, spatial and temporal data. Here, the authors analyse 290,000 genomes sampled in 2021 to demonstrate the value of this high coverage, detailed data set.

Mark P. Khurana
Jacob Curran-Sebastian
Samir Bhatt
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer

Nadia Øgaard
Sarah Østrup Jensen
Claus Lindbjerg Andersen
ResearchOpen Access10 Oct 2024
British Journal of Cancer

Volume: 131, P: 1707-1715
SARS-CoV-2 detection using reverse transcription strand invasion based amplification and a portable compact size instrument

Maiken W. Rosenstierne
Shreya Joshi
Peter Warthoe
ResearchOpen Access15 Nov 2021
Scientific Reports

Volume: 11, P: 1-13
Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA_A receptors

Christina Birkedahl Falk-Petersen
Tsonko M. Tsonkov
Petrine Wellendorph
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Transcriptional regulator PRDM12 is essential for human pain perception

Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus.

Ya-Chun Chen
Michaela Auer-Grumbach
Jan Senderek
Research25 May 2015
Nature Genetics

Volume: 47, P: 803-808
Pulmonologists-level lung cancer detection based on standard blood test results and smoking status using an explainable machine learning approach

Ricco Noel Hansen Flyckt
Louise Sjodsholm
Abdolrahman Peimankar
ResearchOpen Access24 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria

Stig Hill Christiansen
Ronan A. Murphy
Thomas Vorup-Jensen
ResearchOpen Access15 Nov 2017
Scientific Reports

Volume: 7, P: 1-16
Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity

Jens Magnus Bernth Jensen
Mikkel Steen Petersen
Steffen Thiel
ResearchOpen Access12 Mar 2020
Scientific Reports

Volume: 10, P: 1-13
Mosaics and moles

Lone Sunde
Isa Niemann
Lars Bolund
Research08 Jun 2011
European Journal of Human Genetics

Volume: 19, P: 1026-1031
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Inge M. M. Lakeman
Alexandra J. van den Broek
Marjanka K. Schmidt
ResearchOpen Access10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1726-1737
CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

Tomas Strucko
Line Due Buron
Uffe Hasbro Mortensen
ResearchOpen Access30 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes

Nanna Bæk Møller
Desirée Sofie Boonen
Thorkild Terkelsen
ResearchOpen Access26 May 2023
Scientific Reports

Volume: 13, P: 1-11
The myeloarchitecture of impulsivity: premature responding in youth is associated with decreased myelination of ventral putamen

Camilla L. Nord
Seung-Goo Kim
Valerie Voon
Research15 Feb 2019
Neuropsychopharmacology

Volume: 44, P: 1216-1223
Author Correction: Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes

Nanna Bæk Møller
Desirée Sofie Boonen
Thorkild Terkelsen
Amendments and CorrectionsOpen Access15 Sept 2023
Scientific Reports

Volume: 13, P: 1-2
Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation

Maria Rossing
Anders Albrechtsen
Thomas vO Hansen
Research13 Oct 2016
Journal of Human Genetics

Volume: 62, P: 151-157

Search

LDL receptor-GFP fusion proteins: new tools for the characterisation of disease-causing mutations in the LDL receptor gene

Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms.

A second serine protease associated with mannan-binding lectin that activates complement

Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Correction: Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception

The optical afterglow of the short γ-ray burst GRB 050709

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

No supernovae associated with two long-duration γ-ray bursts

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells

Astrocytic GABA transporter activity modulates excitatory neurotransmission

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Comparison of temporal artery ultrasound versus biopsy in the diagnosis of giant cell arteritis

High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer

SARS-CoV-2 detection using reverse transcription strand invasion based amplification and a portable compact size instrument

Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA_A receptors

Transcriptional regulator PRDM12 is essential for human pain perception

Pulmonologists-level lung cancer detection based on standard blood test results and smoking status using an explainable machine learning approach

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria

Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity

Mosaics and moles

The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes

The myeloarchitecture of impulsivity: premature responding in youth is associated with decreased myelination of ventral putamen

Author Correction: Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes

Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation

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