Nature Search

Recent origin of HLA-DRB1 alleles and implications for human evolution

Tomas F. Bergström
Agnetha Josefsson
Ulf Gyllensten
Research01 Mar 1998
Nature Genetics

Volume: 18, P: 237-242
Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

Mats Sundvall
Johan Jirholt
Rikard Holmdahl
Research01 Jul 1995
Nature Genetics

Volume: 10, P: 313-317
Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611

Hans W. Jansen
Rudi Lurz
Ulf R. Rapp
Research19 Jan 1984
Nature

Volume: 307, P: 281-284
Effects of Maternal Diabetes or In Vitro Hyperglycemia on Uptake of Palmitic and Arachidonic Acid by Rat Embryos

Elisabeth Engström
Åsa Haglund
Ulf J Eriksson
Research01 Aug 1991
Pediatric Research

Volume: 30, P: 150-153
Serine- and threonine-specific protein kinase activities of purified gag–mil and gag–raf proteins

Karin Moelling
Barbara Heimann
Thomas Sander
Research06 Dec 1984
Nature

Volume: 312, P: 558-561
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Laura Schmidt
Fuh-Mei Duh
Berton Zbar
Research01 May 1997
Nature Genetics

Volume: 16, P: 68-73
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

Activation of Toll-like receptor (TLR) is generally associated with increased immune activity. Here, the authors show, using syngeneic mouse models, that combined deficiency of TLR 3/7/9 in the host induces an inflamed tumour phenotype and results in T cell dependent tumour regression after an initial growth.

Johanna C. Klein
Katrin Moses
Sven Brandau
ResearchOpen Access16 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Germinal centres: role in B-cell physiology and malignancy

Germinal centres are the main source of memory B cells and plasma cells that produce high-affinity antibodies in the body. In this Review, Ulf Klein and Riccardo Dalla-Favera describe the relationship between the cellular and molecular dynamics of germinal centres and the pathogenesis of B-cell lymphomas.

Ulf Klein
Riccardo Dalla-Favera
Reviews01 Jan 2008
Nature Reviews Immunology

Volume: 8, P: 22-33
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

The PSA (KLK3) genetic variant rs17632542 is associated with reduced prostate cancer risk and lower serum PSA levels, although the underlying reasons are unclear. Here, the authors show that this PSA variant reduced proteolytic activity and leads to smaller tumours, but also increases invasion and bone metastasis, indicating its dual risk association depending on tumour context; the variant is associated with both lower risk and poor clinical outcomes.

Srilakshmi Srinivasan
Thomas Kryza
Jyotsna Batra
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-21
Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

Dewald et al. show a high Spike-IgG seroprevalence (95%) in a multicenter study with 1,411 participants. They determined a substantially reduced serum neutralization against the SARS-CoV-2 VOCs BA.4/5 and BQ.1.1. and explored predictive factors of neutralizing activity.

Felix Dewald
Martin Pirkl
Florian Klein
ResearchOpen Access19 May 2023
Nature Communications

Volume: 14, P: 1-13
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

Ke Wang
Amit Goldenberg
Hannah Moshontz
Research02 Aug 2021
Nature Human Behaviour

Volume: 5, P: 1089-1110
Plot-scale evidence of tundra vegetation change and links to recent summer warming

Satellite data suggest that contemporary climate warming has already resulted in increased productivity and shrub biomass over much of the Arctic, but plot-level evidence for vegetation transformation remains sparse. Now research provides plot-scale evidence linking changes in vascular plant abundance to local summer warming in widely dispersed tundra locations across the globe.

Sarah C. Elmendorf
Gregory H. R. Henry
Sonja Wipf
Research08 Apr 2012
Nature Climate Change

Volume: 2, P: 453-457
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T_H2 responses

This paper shows that regulatory T (T_reg) cells express the transcription factor IRF4, which is essential for the differentiation of T_H2 effector cells. IRF4 depletion in T_reg cells induces T_H2-driven autoimmune disease, leading the authors to suggest that IRF4 directs a module within T_reg cells that selectively suppresses T_H2 responses.

Ye Zheng
Ashutosh Chaudhry
Alexander Y. Rudensky
Research01 Feb 2009
Nature

Volume: 458, P: 351-356
Mitochondrial genome variation and the origin of modern humans

Max Ingman
Henrik Kaessmann
Ulf Gyllensten
Research07 Dec 2000
Nature

Volume: 408, P: 708-713
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.

Elena Schmidt
Ines Dhaouadi
Jan-Wilhelm Kornfeld
ResearchOpen Access06 Sept 2018
Nature Communications

Volume: 9, P: 1-16
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

A study of patients with COVID-19 and healthy donors found CD4⁺ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined.

Julian Braun
Lucie Loyal
Andreas Thiel
Research29 Jul 2020
Nature

Volume: 587, P: 270-274
Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation

Vera M Kalscheuer
Kristine Freude
Hans-Hilger Ropers
Research23 Nov 2003
Nature Genetics

Volume: 35, P: 313-315
Plant functional trait change across a warming tundra biome

Analyses of the relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.

Anne D. Bjorkman
Isla H. Myers-Smith
Evan Weiher
Research26 Sept 2018
Nature

Volume: 562, P: 57-62
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

The nuclear factor kappa B subunit c-Rel acts as a master regulator of metabolism and signalling in epithelial cells and macrophages that drives inflammation and fibrogenesis in various models of fibrosis.

Jack Leslie
Marina García Macia
Fiona Oakley
Research09 Nov 2020
Nature Metabolism

Volume: 2, P: 1350-1367
Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

The freshwater microcrustacean Daphnia pulex forms defensive neckteeth in response to a collection of chemical cues (the kairomone), now identified as certain fatty acids conjugated to glutamine, released during digestion by its predator Chaoborus.

Linda C. Weiss
Bauke Albada
Ralph Tollrian
Research14 Nov 2018
Nature Chemical Biology

Volume: 14, P: 1133-1139
Ocean acidification reduces transfer of essential biomolecules in a natural plankton community

J. Rafael Bermúdez
Ulf Riebesell
Monika Winder
ResearchOpen Access21 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

CRISPR/Cas9 technology has been used for genome engineering in vivo. Here, the authors use a transfection technique to deliver multiple guide RNAs to the pancreas of adult mice, allowing genetic screening and chromosome engineering in pancreatic cancer.

Roman Maresch
Sebastian Mueller
Roland Rad
ResearchOpen Access26 Feb 2016
Nature Communications

Volume: 7, P: 1-13
Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt

Ulf K. Radunski
Johannes Kluwe
Daniel Benten
ResearchOpen Access16 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Directing traffic in the germinal center roundabout

B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

Jagan R. Muppidi
Ulf Klein
News & Views18 May 2020
Nature Immunology

Volume: 21, P: 599-601
Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates

Lars Franken
Marika Klein
Christian Kurts
ResearchOpen Access11 Aug 2015
Scientific Reports

Volume: 5, P: 1-10
Repetitive magnetic stimulation induces plasticity of inhibitory synapses

Repetitive transcranial magnetic stimulation (rTMS) is widely used as a therapeutic tool yet its effect on inhibitory networks in the brain has not been studied. Here, the authors demonstrate that 10Hz rTMS specifically reduces dendritic inhibition onto pyramidal neurons accompanied by remodeling of postsynaptic gephyrin clusters.

Maximilian Lenz
Christos Galanis
Andreas Vlachos
ResearchOpen Access08 Jan 2016
Nature Communications

Volume: 7, P: 1-13
An essential role for the IL-2 receptor in T_reg cell function

The cytokine receptor IL-2R is essential for the development of T_reg cells; therefore, it has been difficult to separate this from its role in the suppressive function of T_reg cells. Rudensky and colleagues use various genetic systems to show that capture of IL-2 by IL-2R is important for suppression of CD8⁺ T cells but not that of CD4⁺ T cells.

Takatoshi Chinen
Arun K Kannan
Alexander Y Rudensky
Research05 Sept 2016
Nature Immunology

Volume: 17, P: 1322-1333
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

Ulf Klein
Stefano Casola
Riccardo Dalla-Favera
Research11 Jun 2006
Nature Immunology

Volume: 7, P: 773-782
Reverse engineering of regulatory networks in human B cells

Katia Basso
Adam A Margolin
Andrea Califano
Research20 Mar 2005
Nature Genetics

Volume: 37, P: 382-390
Individual reproductive success in Norway spruce natural populations depends on growth rate, age and sensitivity to temperature

Camilla Avanzi
Katrin Heer
Andrea Piotti
Research16 Mar 2020
Heredity

Volume: 124, P: 685-698
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Jack Leslie
Marina García Macia
Fiona Oakley
Amendments and Corrections10 Dec 2020
Nature Metabolism

Volume: 3, P: 118-119
Diabetes in Pregnancy: Fetal Macrosomia, Hyperinsulinism, and Islet Hyperplasia in the Offspring of Rats Subjected to Temporary Protein-Energy Malnutrition Early in Life

Ulf J Eriksson
Ingemar Swenne
Research01 Dec 1993
Pediatric Research

Volume: 34, P: 791-795
B cells ferment sugar before they (affinity) mature

Naive B cells activated during infection enter the germinal center (GC) reaction, in which high-affinity antibodies are generated. A new study has uncovered a distinct metabolic requirement for B cells poised to undergo the GC reaction, whose activation required lactate dehydrogenase A-dependent aerobic glycolysis.

Rebecca J. Brownlie
Ulf Klein
News & Views26 Jun 2023
Nature Immunology

Volume: 24, P: 1217-1219
Regulation of c-myc expression by Ras/Raf signalling

Eugen Kerkhoff
Roland Houben
Ulf R Rapp
Research23 Jan 1998
Oncogene

Volume: 16, P: 211-216
Losing control of nutrient sensing in the germinal centre drives lymphomagenesis

The gene encoding the RagC GTPase (RRAGC), an activator of a nutrient-sensing pathway that drives cellular anabolism, is mutated in 15% of follicular lymphoma cases. A new study provides evidence that RRAGC mutations promote lymphomagenesis by distorting the nutrient-dependent control of paracrine signals from the microenvironment, thus enhancing B-cell activation.

Ulf Klein
News & Views19 Aug 2019
Nature Metabolism

Volume: 1, P: 750-751
Preoperative arterial and venous CT radiomics for survival prediction after pylorus preserving pancreatoduodenectomy in pancreatic head cancer

Annika Rastkhiz
Ali Rastkhiz
Teresa Lemainque
ResearchOpen Access10 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

Mikael S Lindström
Ulf Klangby
Klas G Wiman
Research19 Apr 2001
Oncogene

Volume: 20, P: 2171-2177
Dynamics of B cells in germinal centres

The germinal centre (GC) reaction is a highly complex and regulated process. As described in this Review, recent studies have revealed dynamic cellular states in the GC, the requirements for selection of B cells that express high-affinity antibodies and the recirculation of B cells between zones of the GC.

Nilushi S. De Silva
Ulf Klein
Reviews06 Feb 2015
Nature Reviews Immunology

Volume: 15, P: 137-148
Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

Modulatory proteins ensure that transcription factors are active when and where they should be. Wang et al. describe an algorithm for identifying modulators from a compendium of gene expression profiles and experimentally validate four diverse modulators of the MYC oncogene in human B cells.

Kai Wang
Masumichi Saito
Andrea Califano
Research09 Sept 2009
Nature Biotechnology

Volume: 27, P: 829-837
Correlations between Maternal Metabolism and Deranged Development in the Offspring of Normal and Diabetic Rats

Johan Styrud
Lennart Thunberg
Ulf J Eriksson
Research01 Mar 1995
Pediatric Research

Volume: 37, P: 343-353
Cerebrospinal Fluid Levels of Monoamine Metabolites

Elias Eriksson
Christer Alling
Ulf Berggren
Research01 Nov 1994
Neuropsychopharmacology

Volume: 11, P: 201-213
Multiplex enzyme activity imaging by MALDI-IMS of substrate library conversions

Oliver Klein
Akvile Haeckel
Eyk Schellenberger
ResearchOpen Access23 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma

Dayana Herrera-Rios
Guanzhang Li
Ulf Dietrich Kahlert
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
The International Climate Psychology Collaboration: Climate change-related data collected from 63 countries

Kimberly C. Doell
Boryana Todorova
Jay J. Van Bavel
ResearchOpen Access01 Oct 2024
Scientific Data

Volume: 11, P: 1-17
Cross-cultural data on romantic love and mate preferences from 117,293 participants across 175 countries

Marta Kowal
Piotr Sorokowski
Filipe Prazeres
ResearchOpen Access01 Jul 2025
Scientific Data

Volume: 12, P: 1-12
Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma

Andrei Alimov
Maria Kost-Alimova
Eugene R Zabarovsky
Research13 Mar 2000
Oncogene

Volume: 19, P: 1392-1399
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis

Guilhem Lalle
Raphaëlle Lautraite
Yenkel Grinberg-Bleyer
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study

S K Kumar
J H Lee
Jeffrey Zonder
Research29 Jul 2011
Leukemia

Volume: 26, P: 149-157

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