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Showing 1–10 of 10 results
Advanced filters: Author: Ulrich Stelzl Clear advanced filters

  • ATGL is a key enzyme in intracellular lipolysis. Here, the authors use deep mutational scanning to define the determinants of protein interaction between ATGL and its regulatory partners, gaining insights into lipolysis mechanisms in cells.

    • Johanna M. Kohlmayr
    • Gernot F. Grabner
    • Ulrich Stelzl
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Combining yeast two-hybrid data with mass-spectrometry and structural data provides a detailed view of the E. coli interactome.

    • Ulrich Stelzl
    News & Views
    Nature Biotechnology
    Volume: 32, P: 241-243

  • A framework based on numerous empirical data, including protein-protein interaction reference sets, provides parameters for assessing the quality and coverage of protein-protein interaction datasets and estimation of the size of the human interactome. Braun et al., also in this issue, use the reference sets to help derive confidence scores for individual protein-protein interactions.

    • Kavitha Venkatesan
    • Jean-François Rual
    • Marc Vidal
    Research
    Nature Methods
    Volume: 6, P: 83-90

  • A reverse two-hybrid approach combined with massively parallel programmed mutagenesis and sequencing allows profiling protein interaction determinants at amino-acid resolution, as demonstrated by identifying interaction-disrupting mutations in a cilia protein complex associated with Bardet–Biedl syndrome.

    • Jonathan Woodsmith
    • Luise Apelt
    • Ulrich Stelzl
    Research
    Nature Methods
    Volume: 14, P: 1213-1221

  • Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

    • Sebastian J. Hofer
    • Ioanna Daskalaki
    • Frank Madeo
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1571-1584

  • How intracellular cAMP activate PKA is well-characterized, but PKA inactivation remains poorly understood. Here, Rinaldi et al. show that CHIP/HSP70 ubiquitinates the catalytic subunit of PKA, with implications for the human disease spinocerebellar ataxia 16, as patients often have CHIP mutations.

    • Laura Rinaldi
    • Rossella Delle Donne
    • Antonio Feliciello
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Coupling distances between synaptic vesicles and Ca2+ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca2+ channels and synaptic vesicles.

    • Mathias A Böhme
    • Christina Beis
    • Stephan J Sigrist
    Research
    Nature Neuroscience
    Volume: 19, P: 1311-1320