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Showing 1–13 of 13 results
Advanced filters: Author: Ulrich Tepass Clear advanced filters

  • Tepass and colleagues use a series of mutant α-catenin forms to study the role of this protein in Drosophila in vivo. Their data support a model in which monomeric α-catenin links the cadherin–β-catenin complex at adherens junction to the actin cytoskeleton.

    • Ridhdhi Desai
    • Ritu Sarpal
    • Ulrich Tepass
    Research
    Nature Cell Biology
    Volume: 15, P: 261-273

  • An analysis of fruit-fly embryos reveals that receptor proteins of the Toll family direct the oriented cell rearrangements required for the elongation of the head-to-tail axis during development. See Article p.523

    • Ulrich Tepass
    News & Views
    Nature
    Volume: 515, P: 499-501

  • Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.

    • Dorothea Godt
    • Ulrich Tepass
    News & Views
    Nature Cell Biology
    Volume: 11, P: 536-538

  • Recent work has advanced our understanding of the molecular organization of adherens junctions and how cadherin–catenin complexes at their core engage actin, microtubules and the endocytic machinery. This provides insight into how adherens junctions can maintain tissue architecture and facilitate cell movement during tissue morphogenesis.

    • Tony J. C. Harris
    • Ulrich Tepass
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 502-514

  • Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.

    • Noboru Ishiyama
    • Ritu Sarpal
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Polarization of cells is critical for the development of multicellular organisms and defects in this process contribute to several diseases. Here, a novel protein pathway is identified that is important for polarity formation during early embryogenesis in Drosophila, and appears to be conserved in mammalian cells.

    • Patrick Laprise
    • Kimberly M. Lau
    • Ulrich Tepass
    Research
    Nature
    Volume: 459, P: 1141-1145

  • Talin is a core component of the integrin adhesion complex. It is now shown that talin also regulates transcription, an activity that is apparently independent of its interaction with integrins. Talin represses the expression of Drosophila melanogaster DE-cadherin through an unknown molecular mechanism.

    • Ulrich Tepass
    • Dorothea Godt
    News & Views
    Nature Cell Biology
    Volume: 7, P: 443-444

  • Houses have roofs and foundations which are built of different materials and require upkeep. Likewise, cells — especially for instance those that form an epithelial sheet — have a top and bottom, and the right proteins have to be directed to the right place throughout the cells' lives. A molecule called Scribble now emerges as a central player in the maintenance of cell polarity in the fruitflyDrosophila.

    • Mark Peifer
    • Ulrich Tepass
    News & Views
    Nature
    Volume: 403, P: 611-612

  • Chordate claudins are core components of tight junctions. By contrast, VAB-9, a nematode four-pass transmembrane protein related to claudins, localizes to adherens junctions and contributes to cell adhesion and actin–plasma membrane association.

    • Ulrich Tepass
    News & Views
    Nature Cell Biology
    Volume: 5, P: 595-597