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Showing 1–5 of 5 results
Advanced filters: Author: Ulrike A. Nuber Clear advanced filters

  • A series of FRET-based β-arrestin2 biosensors are used to study the dynamics and conformational changes that occur when β-arrestin2 binds to and dissociates from the β2-adrenergic receptor in living cells; results show that after β-arrestin2 dissociates from the β2-adrenergic receptor, it stays at the cell membrane in an active conformation for a while, indicating that β-arrestin is able to signal in a G-protein-coupled receptor (GPCR)-free state.

    • Susanne Nuber
    • Ulrike Zabel
    • Carsten Hoffmann
    Research
    Nature
    Volume: 531, P: 661-664

  • Why and how mutations in genes encoding BAF complex components lead to distinct disease entitites remains unresolved. In this study, authors establish the first Smarcb1 mutant mouse model with multiple brain abnormalities recapitulating human Coffin–Siris syndrome and show that one prominent midline abnormality, corpus callosum agenesis, is due to midline glia aberrations.

    • Alina Filatova
    • Linda K. Rey
    • Ulrike A. Nuber
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The authors uncover a mechanism for the known antitumor effect exerted by neural precursor cells (NPCs). NPCs migrate into tumors in vivo and secrete endovanilloids, which act as agonists for TRPV1, their receptor expressed by glioma cells. TRPV1 activation causes ER stress and glioma cell death. The reported elevated concentration of TRPV1 in human gliomas and the antitumor effect of synthetic vanilloids suggest that this pathway could be a point of therapeutic intervention and that differential NPC activity, such as that modulated by age, could be a factor influencing brain tumorigenesis.

    • Kristin Stock
    • Jitender Kumar
    • Rainer Glass
    Research
    Nature Medicine
    Volume: 18, P: 1232-1238