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Showing 1–3 of 3 results
Advanced filters: Author: Umeshkumar M. Vekariya Clear advanced filters

  • Here the authors reveal a two-step spatiotemporal regulation of (Polθ)-mediated end-joining (TMEJ). First, PARP1 PARylates Polθ and facilitates its recruitment to the vicinity of DNA damage sites in an inactivated state. PARG subsequently activates TMEJ by removing repressive PAR marks on Polθ.

    • Umeshkumar Vekariya
    • Leonid Minakhin
    • Tomasz Skorski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Polθ helicase is crucial for DNA repair and a target for precision medicine for cancer therapy. Here, the authors reveal the mechanism of action of the small-molecule inhibitor AB25583, and show its high specificity and selective killing of BRCA1/2– cancer cells and synergy with olaparib.

    • Fumiaki Ito
    • Ziyuan Li
    • Richard T. Pomerantz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13