Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–15 of 15 results
Advanced filters: Author: Ursula Fearon Clear advanced filters

  • α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors report that pharmacological inhibition of ABHD11 modulates T-cell effector function via increased 24,25-epoxycholesterol biosynthesis and subsequent liver X receptor activation.

    • Benjamin J. Jenkins
    • Yasmin R. Jenkins
    • Nicholas Jones
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling to promote tumour survival.

    • Eunsun Kim
    • Amanda Lisby
    • Patrick Viatour
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Here the authors use positron emission tomography to visualize fibroblasts in patients with arthritis and combined with spatial transcriptomic data show that these cells undergo a phenotypic shift upon resolution of inflammation. A CD200+DKK3+ fibroblast subset promotes this resolution by inhibiting tumor necrosis factor and interleukin-17A.

    • Simon Rauber
    • Hashem Mohammadian
    • Andreas Ramming
    Research
    Nature Immunology
    Volume: 25, P: 682-692

  • Number of IL-9-expressing ILC2s are elevated in patients with inflammatory arthritis during remission, and these cells are critical in mice for the resolution of inflammatory arthritis via regulatory T cell induction. Delivery of DNA minicircles encoding IL-9 into inflamed joints ameliorates mouse experimental arthritis, suggesting possible therapeutic applications.

    • Simon Rauber
    • Markus Luber
    • Andreas Ramming
    Research
    Nature Medicine
    Volume: 23, P: 938-944

  • In this article, the authors provide a comprehensive and timely review of the mechanisms and consequences of hypoxia in the biology of inflammatory arthritis, with a focus on mitochondrial function, hypoxia signalling pathways in rheumatoid arthritis, and therapeutic implications.

    • Ursula Fearon
    • Mary Canavan
    • Douglas J. Veale
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 385-397

  • Cell metabolism has long been at the forefront of tumour biology, but in the past decade the importance of cellular bioenergetics has been increasingly recognized in regulating immune cell function. Mechanistic studies in 2018 have highlighted cell metabolism as a potential therapeutic target for the treatment of rheumatoid arthritis.

    • Trudy McGarry
    • Ursula Fearon
    News & Views
    Nature Reviews Rheumatology
    Volume: 15, P: 70-72

  • The synovium is the main target tissue of inflammatory arthritides such as rheumatoid arthritis and psoriatic arthritis. In 2019, new technologies for examining the molecular characteristics of specific cell subsets have enabled advances in our understanding of the architecture of synovial lymphoid aggregates, macrophage infiltrates and synovial fibroblast subsets.

    • Douglas J. Veale
    • Ursula Fearon
    News & Views
    Nature Reviews Rheumatology
    Volume: 16, P: 67-68

  • Advances in synovial tissue research have improved our understanding of inflammatory arthritides, particularly rheumatoid arthritis, and have identified potential biomarkers that could be used for diagnosis, disease stratification, and predicting disease course and treatment response.

    • Carl Orr
    • Elsa Vieira-Sousa
    • Douglas J. Veale
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 463-475

  • Metabolic reprogramming of immune cells and somatic cells alike has a role in perpetuating disease in the joints. In this Review, the authors examine metabolic alterations that occur in the main cells of the joint tissues during osteoarthritis.

    • Ali Mobasheri
    • Margaret P. Rayman
    • Ursula Fearon
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 302-311

  • In this Review, the authors discuss how the inflammatory, hypoxic environment of joints in rheumatoid arthritis affects metabolism in fibroblasts, endothelial cells and immune cells. Understanding the competing requirements of these cells can enable effective therapeutic targeting of synovial metabolism.

    • Ursula Fearon
    • Megan M. Hanlon
    • Douglas J. Veale
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 398-414