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Showing 1–2 of 2 results
Advanced filters: Author: Uwe Schlomann Clear advanced filters

  • Expression of ADAM8, a metalloprotease disintegrin, correlates with worse prognosis in pancreatic adenocarcinoma (PDAC). Here Schlomann et al. show that ADAM8 promotes PDAC invasiveness, and develop a peptide inhibitor that blocks ADAM8 function and impedes PDAC progression in mouse models.

    • Uwe Schlomann
    • Garrit Koller
    • Jörg W. Bartsch
    Research
    Nature Communications
    Volume: 6, P: 1-16

  • Heart failure with preserved ejection fraction (HFpEF), which can be driven by obesity and hypertension, has a high prevalence but limited treatment options. Here, the authors show that nitro-oleic acid restores mitochondrial function and improves heart failure symptoms in a mouse model of HFpEF.

    • Marion Müller
    • Torben Schubert
    • Anna Klinke
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18