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Showing 1–6 of 6 results
Advanced filters: Author: V Rakyan Clear advanced filters

  • An inability to estimate absolute DNA methylation levels has slowed progress in understanding the role of this epigenetic modification in health and disease. Down et al. describe an algorithm for analyzing methylated DNA immunoprecipitation profiles generated using either high-throughput sequencing or oligonucleotide arrays.

    • Thomas A Down
    • Vardhman K Rakyan
    • Stephan Beck
    Research
    Nature Biotechnology
    Volume: 26, P: 779-785

  • It has long been recognized that some phenotypic variation in mammals cannot be explained by known genetic or environmental variables. Here, the authors show that the absence of Nnat expression is associated with polyphenism in mice with the same genotype. Broadly consistent effects are also found in humans.

    • Michelle L. Holland
    • Vardhman K. Rakyan
    News & Views
    Nature Metabolism
    Volume: 4, P: 1091-1092

  • Technological advances now allow large-scale studies of human disease-associated epigenetic variation, specifically variation in DNA methylation. Such epigenome-wide association studies present novel opportunities, but, as discussed here, they also create new challenges that are not encountered in genome-wide association studies.

    • Vardhman K. Rakyan
    • Thomas A. Down
    • Stephan Beck
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 529-541