MAT2A/MAT2B induction is required for hepatic stellate cell activation and FOXM1 is implicated in liver inflammation and fibrosis, but whether they crosstalk in liver disease is unknown. Here, the authors show that upregulation of the FOXM1/MAT2A/MAT2B axis drives liver inflammation and fibrosis.
- Bing Yang
- Liqing Lu
- Shelly C. Lu