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Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif

Aminoacyl-tRNA synthetases translate the genetic code. These enzymes harbor signature catalytic motifs dating from their ancient ancestors. A natural variation of one of the stated motifs was discovered and linked to antibiotic hyper-resistance.

A. Brkic
M. Leibundgut
I. Gruic-Sovulj
ResearchOpen Access07 Sept 2023
Nature Communications

Volume: 14, P: 1-12
Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Crystal structures for all enzyme states of leucyl-tRNA synthetase in Neisseria gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.

Luping Pang
Vladimir Zanki
Stephen D. Weeks
ResearchOpen Access29 Aug 2022
Communications Biology

Volume: 5, P: 1-12

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Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif

Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

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