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Showing 1–4 of 4 results
Advanced filters: Author: VOLKER BRENDEL Clear advanced filters

  • The ontogeny of conventional and plasmacytoid dendritic cells (DC) and how these two cell types are related is not fully known. Here the authors identify a pool of bone marrow precursor cells expressing Ly6D Siglec-H and Zbtb46 that can differentiate into either cDC or pDC and show that type I IFN can limit cDC and favor pDC output from these precursors.

    • Konstantin Lutz
    • Andrea Musumeci
    • Anne B. Krug
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a target for the treatment of crystal-induced disease.

    • Shrikant R. Mulay
    • Jyaysi Desai
    • Hans-Joachim Anders
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15