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Showing 1–3 of 3 results
Advanced filters: Author: Vahakn Shahinian Clear advanced filters

  • The challenge of optimizing androgen deprivation therapy (ADT) for prostate cancer has been illustrated by two recent papers. A preclinical study demonstrated that the effects of androgen deprivation on prostatic neoplastic tissue are not necessarily beneficial and a large database analysis showed that practice patterns of ADT are not always in line with recommended guidelines.

    • Vahakn B. Shahinian
    News & Views
    Nature Reviews Urology
    Volume: 10, P: 192-193

  • Androgen deprivation therapy (ADT) is well established as a cause of osteoporosis and increased fracture risk. A study has shown that toremifene reduces fracture risk in men receiving ADT for prostate cancer. The study has substantial limitations, however, and the management of bone disease in these patients remains a challenge.

    • Vahakn B. Shahinian
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 9-10

  • The lack of generalizability and reproducibility of machine learning models in medical applications is increasingly recognized as a substantial barrier to implementing such approaches in real-world clinical settings. Highlighting this issue, Jie Cao et al. aim to reproduce a recent acute kidney injury prediction model, and find persistent discrepancies in model performance in different subgroups.

    • Jie Cao
    • Xiaosong Zhang
    • Karandeep Singh
    Research
    Nature Machine Intelligence
    Volume: 4, P: 1121-1129