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Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome

By mapping oxidatively damaged bases and abasic sites at single-nucleotide resolution in human cells, Takhaveev et al. observed transcription-related strand biases, patterns mirroring cancer mutational signatures, and captured the action of the anticancer drug irofulven.

Vakil Takhaveev
Nikolai J. L. Püllen
Shana J. Sturla
ResearchOpen Access31 Oct 2025
Nature Chemical Biology

P: 1-12
Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle

Takhaveev et al. use single-cell methods and mathematical modeling to reveal distinct waves in the synthesis rates of proteins, lipids and polysaccharides during the budding yeast cell cycle and relate them to flux changes in primary metabolism.

Vakil Takhaveev
Serdar Özsezen
Matthias Heinemann
ResearchOpen Access27 Feb 2023
Nature Metabolism

Volume: 5, P: 294-313
Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

The antitumor drug trabectedin is more toxic to DNA-repair-proficient cells. Here the authors show that this is caused by persistent DNA breaks induced from an abortive repair reaction and develop “TRABI-Seq” to map the breaks to transcribed regions of the genome. Trabectedin may thus be used as a diagnostic and therapeutic in precision oncology.

Kook Son
Vakil Takhaveev
Orlando D. Schärer
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-15
RNA polymerase III limits longevity downstream of TORC1

RNA polymerase III is a key evolutionarily conserved regulator of longevity that may have potential as a therapeutic target for age-related conditions.

Danny Filer
Maximillian A. Thompson
Nazif Alic
Research29 Nov 2017
Nature

Volume: 552, P: 263-267

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Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome

Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

RNA polymerase III limits longevity downstream of TORC1

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