Human DNase I is shown to be overexpressed in hypoxic environments in vitro and to be incorporated into human hepatitis B virus (HBV) particles, resulting in virions devoid of genomic DNA. These findings might help explain the low levels of circulating HBV DNA commonly observed in cirrhotic livers and liver tumours.
- Camille Hallez
- Xiongxiong Li
- Jean-Pierre Vartanian
