Nature Search

Neural regulation of immunity: molecular mechanisms and clinical translation

Neural pathways regulate immune responses and inflammation. Recent research using technological advances in molecular genetics has provided important insights into the functional anatomy and cellular and molecular mechanisms of this regulation. These advances resulted in clinical trials exploring neuromodulation in the treatment of inflammatory and autoimmune disorders.

Valentin A Pavlov
Kevin J Tracey
Reviews16 Jan 2017
Nature Neuroscience

Volume: 20, P: 156-166
Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

Cosimo Posth
He Yu
Johannes Krause
ResearchOpen Access01 Mar 2023
Nature

Volume: 615, P: 117-126
Neural representation of cytokines by vagal sensory neurons

This study showed that vagal sensory neurons in the nodose ganglia selectively encode specific cytokines, enabling real-time body-brain communication of immune signals. This neural encoding of cytokines is disrupted during inflammation associated with a colitis model.

Tomás S. Huerta
Adrian C. Chen
Eric H. Chang
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-15
MicroRNA-200 family expression analysis in metastatic clear cell renal cell carcinoma patients

Irina R. Gilyazova
Elizaveta A. Klimentova
Elsa K. Khusnutdinova
Research04 Nov 2019
Cancer Gene Therapy

Volume: 27, P: 768-772
The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice

Aidan Falvey
Santhoshi P. Palandira
Valentin A. Pavlov
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-13
The vagus nerve and the inflammatory reflex—linking immunity and metabolism

Vagus-nerve signalling regulates immune activation and metabolic homeostasis. Dysregulation of metabolism and immune function in obesity results in chronic inflammation associated with insulin resistance and type 2 diabetes mellitus. In this Review, exploiting the vagus-nerve-mediated inflammatory reflex in the treatment of obesity-related disorders is discussed.

Valentin A. Pavlov
Kevin J. Tracey
Reviews21 Nov 2012
Nature Reviews Endocrinology

Volume: 8, P: 743-754
Infection risks and biopsy-associated complications in prostate cancer diagnosis: a review of recent literatures

Pavlov Valentin Nikolaevich
Akinyemi Olalekan Samuel
Fagbemi Adeleke Adesegun
Reviews05 Dec 2025
Prostate Cancer and Prostatic Diseases

P: 1-13
Blood pressure regulation by CD4⁺ lymphocytes expressing choline acetyltransferase

A CD4 T-cell population expressing choline acetyltransferase is shown to contribute to blood pressure regulation.

Peder S Olofsson
Benjamin E Steinberg
Kevin J Tracey
Research12 Sept 2016
Nature Biotechnology

Volume: 34, P: 1066-1071
Light-driven anisotropy of 2D metal-organic framework single crystal for repeatable optical modulation

Structural transformations offer a route to control functional properties but it is difficult to design metal-organic frameworks with multiple and fast transformations. Here, a 2D metal-organic framework was designed with continuous structural transformations driven by light and used for optical modulation.

Yuliya A. Kenzhebayeva
Nikita K. Kulachenkov
Valentin A. Milichko
ResearchOpen Access10 Apr 2024
Communications Materials

Volume: 5, P: 1-11
Cholinergic stimulation with pyridostigmine modulates a heart-spleen axis after acute myocardial infarction in spontaneous hypertensive rats

Robson Luiz Bandoni
Pamela Nithzi Bricher Choque
Fernanda Marciano Consolim-Colombo
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-13
Bridging cholinergic signalling and inflammation in schizophrenia

Christine N. Metz
Michael Brines
Valentin A. Pavlov
Comments & OpinionOpen Access11 May 2024
Schizophrenia

Volume: 10, P: 1-2

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