Different mechanisms have been implicated in the induction of senescence. Two of these mechanisms, the DNA damage response, which induces a replicative checkpoint, and the formation of heterochromatic foci, which leads to transcriptional repression, are found to act together in oncogene-expressing cells.
- Raffaella Di Micco
- Gabriele Sulli
- Fabrizio d'Adda di Fagagna
