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Advanced filters: Author: Valentina Zappulli Clear advanced filters

Targeting the CBM complex causes T_reg cells to prime tumours for immune checkpoint therapy

Disruption of the CARMA1–BCL10–MALT1 (CBM) signalosome causes T_reg cells to produce IFNγ and develop dominant anti-tumour activity in synergy with anti-PD-1 treatment, and in the absence of autoimmunity.

Mauro Di Pilato
Edward Y. Kim
Thorsten R. Mempel
Research15 May 2019
Nature

Volume: 570, P: 112-116
Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

Pharmacological inhibition of SCD induces lipotoxicity, impairs DNA damage repair, enhances antigen presentation and interferon signaling, and reduces immunosuppressive pathways, fostering an anti-tumor immune response in the TME.

Alessandro Sammarco
Giorgia Guerra
Christian E. Badr
ResearchOpen Access04 Apr 2025
Communications Biology

Volume: 8, P: 1-14
Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles

Mikołaj Piotr Zaborowski
Pike See Cheah
Xandra O. Breakefield
ResearchOpen Access22 Nov 2019
Scientific Reports

Volume: 9, P: 1-16