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Showing 1–3 of 3 results
Advanced filters: Author: Valentina Zorzini Clear advanced filters

  • PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.

    • Johannes Gregor Matthias Rack
    • Qiang Liu
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.

    • Evgeniia Prokhorova
    • Florian Zobel
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The interconnected processes in Escherichia coli K12 governing protein transport, folding and membrane insertion are reviewed.

    • Jozefien De Geyter
    • Alexandra Tsirigotaki
    • Spyridoula Karamanou
    Reviews
    Nature Microbiology
    Volume: 1, P: 1-13