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  • The authors report crystallographic and computational studies that detail how SARS-CoV-2 3CLpro cleaves the host NF-κB Essential Modulator in addition to its canonical viral substrates. The association with the high fitness of SARS-CoV-2 in humans is discussed.

    • Mikhail A. Hameedi
    • Erica T. Prates
    • Daniel Jacobson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15