Defects in human germ-cell (oocyte and sperm) development are the leading cause of infertility in men and women. A germ-cell reporter is now used to quantify and isolate primordial germ cells derived from both male and female human embryonic stem cells. Human DAZL is observed to function in primordial germ-cell formation, whereas the closely related genes DAZ and BOULE promote later stages of meiosis and development of gametes.
- Kehkooi Kee
- Vanessa T. Angeles
- Renee A. Reijo Pera
