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Showing 1–4 of 4 results
Advanced filters: Author: Vanessa Bruat Clear advanced filters

  • Age-related clonal hematopoiesis is associated with risk for diseases like acute myeloid leukemia (AML), yet it is unclear why some individuals do not progress despite having AML driver mutations. Here, the authors use deep learning and population genetics models to investigate how the interplay of positive and negative selection influences AML progression.

    • Kimberly Skead
    • Armande Ang Houle
    • Philip Awadalla
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Individuals with different genotypes may respond differently to environmental variation. Here, Favé et al. find substantial impacts of different environment exposures on the transcriptome and clinical endophenotypes when controlling for genetic ancestry by analyzing data from ∼1000 individuals from a founder population in Quebec.

    • Marie-Julie Favé
    • Fabien C. Lamaze
    • Philip Awadalla
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Whole-genome sequencing analyses of African populations provide insights into continental migration, gene flow and the response to human disease, highlighting the importance of including diverse populations in genomic analyses to understand human ancestry and improve health.

    • Ananyo Choudhury
    • Shaun Aron
    • Neil A. Hanchard
    Research
    Nature
    Volume: 586, P: 741-748