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Showing 1–3 of 3 results
Advanced filters: Author: Vanessa Dusend Clear advanced filters

  • Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.

    • Philipp Makowka
    • Tobias Bruegmann
    • Philipp Sasse
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.

    • Ahmed Wagdi
    • Daniela Malan
    • Tobias Bruegmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18