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Showing 1–2 of 2 results
Advanced filters: Author: Vanja Duric Clear advanced filters

  • Chronic stress can lead to depression. Ronald Duman and his colleagues show that REDD1 expression is increased in the brain of patients with major depressive disorder and is upregulated in the brains of stressed mice. Mice lacking REDD1 were resistant to stress-induced depressive behaviors, and unstressed rats in which REDD1 was artificially increased exhibited depressive behaviors.

    • Kristie T Ota
    • Rong-Jian Liu
    • Ronald S Duman
    Research
    Nature Medicine
    Volume: 20, P: 531-535

  • Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated in the postmortem hippocampus of individuals with depression, and altering the expression of this protein in rats and mice can regulate depressive behaviors and their resistance to stress.

    • Vanja Duric
    • Mounira Banasr
    • Ronald S Duman
    Research
    Nature Medicine
    Volume: 16, P: 1328-1332