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Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs

The specific recognition of a proline-rich motif in the intrinsically disordered region of SF1 by the PRPF40A tandem WW domains is modulated by an intramolecular autoinhibition, suggesting a general mechanism to enhance WW binding selectivity.

Santiago Martínez-Lumbreras
Lena K. Träger
Michael Sattler
ResearchOpen Access08 May 2024
Nature Communications

Volume: 15, P: 1-17

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Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs

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