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Advanced filters: Author: Veda Chokshi Clear advanced filters

  • In mammals, polyploidy is only seen in liver hepatocytes and in trophoblast giant cells in the placenta. Leone and colleagues now show that ploidy is controlled in an antagonistic fashion by canonical E2F transcriptional activators and atypical E2F7 and E2F8 repressors, through the control of G2/M-associated genes.

    • Hui-Zi Chen
    • Madhu M. Ouseph
    • Gustavo Leone
    Research
    Nature Cell Biology
    Volume: 14, P: 1192-1202