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Showing 1–4 of 4 results

Advanced filters: Author: Vera Leber Clear advanced filters

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Geminin regulates DNA replication by binding CDT1 and preventing MCM helicase loading. Using a reconstituted system and structural modelling, the authors find geminin inhibits via steric clash with MCM, not by blocking the CDT1–MCM interface. Combined with CDK activity, it fully halts licensing.

Joshua Tomkins
Lucy V. Edwardes
Christian Speck
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-23
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

The loading of the replicative helicase MCM2-7 is vital for replication fork assembly. Here, the authors reconstituted human MCM2-7 loading and identified the roles of Cdc6 in complex resolution and cancer-associated mutations in Mcm3 recruitment.

Jennifer N. Wells
Lucy V. Edwardes
Christian Speck
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Audio motor training improves mobility and spatial cognition in visually impaired children

Giulia Cappagli
Sara Finocchietti
Monica Gori
ResearchOpen Access01 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells

Tanja Macheiner
Vera Heike Ingeborg Fengler
Karine Sargsyan
ResearchOpen Access21 Oct 2016
Scientific Reports

Volume: 6, P: 1-7

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