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Showing 1–7 of 7 results
Advanced filters: Author: Vera M. Kissling Clear advanced filters

  • The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of Rad50 at the base of the MR structure, and reveal MR head domain oligomerization is required for efficient DNA end resection.

    • Vera M. Kissling
    • Giordano Reginato
    • Matthias Peter
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • MCM8-9 and HROB function together in DNA damage response. Here, the authors describe the mechanism of DNA unwinding by MCM8-9 and its activation by HROB. HROB makes direct contacts with both MCM8 and MCM9 and promotes DNA unwinding downstream of MCM8-9 loading and hexameric ring formation on DNA.

    • Ananya Acharya
    • Hélène Bret
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • A high-affinity complex of histone H1 and prothymosin-α reveals an unexpected interaction mechanism, where the large opposite net charge enables the two proteins to remain highly disordered even in the complex.

    • Alessandro Borgia
    • Madeleine B. Borgia
    • Benjamin Schuler
    Research
    Nature
    Volume: 555, P: 61-66

  • An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.

    • Ananya Acharya
    • Kristina Kasaciunaite
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.

    • Elda Cannavo
    • Dominic Johnson
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14