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Showing 1–17 of 17 results
Advanced filters: Author: Veronique Gouverneur Clear advanced filters

  • Thomas Schlatzer and Véronique Gouverneur discuss why the chemistry of calcium fluoride is challenging, and how imaginative thinking based on fundamental principles can create positive change for the fluorochemical industry.

    • Thomas Schlatzer
    • Véronique Gouverneur
    Comments & Opinion
    Nature Chemistry
    Volume: 17, P: 1434

  • Fluorochemicals are obtained directly from fluorspar activated in water at low temperature, without the requirement to manufacture hydrogen fluoride, a toxic and hazardous gas that is central to the current industrial process.

    • Immo Klose
    • Calum Patel
    • Véronique Gouverneur
    ResearchOpen Access
    Nature
    Volume: 635, P: 359-364

  • Positron emission tomography imaging is an increasingly important technology in drug discovery and development, so there is an urgent need for logistically simple processes that allow access to [18F]CF3 (hetero)arenes. Here, a late-stage [18F]trifluoromethylation of (hetero)aryl iodides from [18F]fluoride and commercially available reagents is described, a process that relies on the in situ preparation of [18F]CuCF3.

    • Mickael Huiban
    • Matthew Tredwell
    • Jan Passchier
    Research
    Nature Chemistry
    Volume: 5, P: 941-944

  • This study highlights a protocol that converts various perfluoroalkyl and polyfluoroalkyl substances (PFASs), including fluoroplastics, into valuable fluorochemicals through a solvent-free mechanochemical process, thereby enabling fluorine recovery and contributing to a sustainable circular fluorine economy.

    • Long Yang
    • Zijun Chen
    • Véronique Gouverneur
    ResearchOpen Access
    Nature
    Volume: 640, P: 100-106

  • The catalytic enantioconvergent nucleophilic fluorination of alkyl halides using inexpensive alkali metal fluorides is a persistent challenge. Now this has been achieved by synergistic hydrogen bonding phase-transfer catalysis combining a chiral bis-urea hydrogen bond donor and an onium salt.

    • Claire Dooley
    • Francesco Ibba
    • Véronique Gouverneur
    ResearchOpen Access
    Nature Catalysis
    Volume: 8, P: 107-115

  • A sophisticated palladium(IV)-based species allows nucleophilic fluoride to react as an electrophilic fluorination reagent. This long-awaited reactivity will be especially useful in the preparation of radiochemically labelled molecules for positron emission tomography studies.

    • Véronique Gouverneur
    News & Views
    Nature Chemistry
    Volume: 4, P: 152-154

  • Calcium difluoride is a source of fluorochemicals, but the reactivity of Ca–F moieties is not well understood. Now a library of molecular Ca–F complexes featuring unique structural motifs has been synthesized, including via fluorochemical defluorination. Studies of mono- and dinuclear systems provided structure–activity relationships for E–F bond formation.

    • Job J. C. Struijs
    • Mathias A. Ellwanger
    • Simon Aldridge
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1473-1480

  • Carbene chemistry is used to introduce difluoromethyl groups labelled with fluorine-18 into compounds for positron emission tomography imaging, using a reagent designed for high molar activity and versatility.

    • Jeroen B. I. Sap
    • Claudio F. Meyer
    • Véronique Gouverneur
    Research
    Nature
    Volume: 606, P: 102-108

  • Post-translational site-selective formation of boronoalanine in proteins enables applications of boron for binding partner capture, footprinting of interactions with reactive oxygen species, proteolytic control and mapping of transient structures.

    • Tim A. Mollner
    • Patrick G. Isenegger
    • Benjamin G. Davis
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 17, P: 1245-1261

  • Automation of new methods for 18F incorporation into unactivated (hetero)arenes for translation to the clinic has progressed slowly. This protocol describes a workflow leading to automated radiosynthesis of the PARP inhibitor [18F]olaparib.

    • Florian Guibbal
    • Patrick G. Isenegger
    • Véronique Gouverneur
    Protocols
    Nature Protocols
    Volume: 15, P: 1525-1541

  • As compared to the drug discovery process, the development of new 18F PET tracers lacks a well-established pipeline that advances compounds from academic research to candidacy for (pre)clinical imaging. In order to bridge the gaps between methodological advances and clinical success, we must rethink the development process from training to implementation.

    • Michael G. Campbell
    • Joel Mercier
    • Tobias Ritter
    Comments & Opinion
    Nature Chemistry
    Volume: 9, P: 1-3

  • This Primer describes contemporary fluorination and fluoroalkylation reactions in chemical synthesis. The authors describe the main fluorination and fluoroalkylation reactions. The many applications of these reactions in pharmaceuticals, imaging agents and agriculture are discussed, along with the history and future of synthetic organofluorine chemistry.

    • Robert Britton
    • Veronique Gouverneur
    • Jinbo Hu
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-22