Nature Search

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations

Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Nilanjana Sadhu
Rinkoo Dalan
John C. Chambers
Research13 May 2025
Nature Cardiovascular Research

Volume: 4, P: 567-583
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
INPP5D regulates inflammasome activation in human microglia

INPP5D/SHIP1 is a microglial-expressed gene that has been associated with Alzheimer’s disease through genetic studies. This study reveals that reduction in INPP5D activity induces activation of the NLRP3-inflammasome in human microglia.

Vicky Chou
Richard V. Pearse II
Tracy L. Young-Pearse
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-23
Shrinking of fishes exacerbates impacts of global ocean changes on marine ecosystems

In the ocean, biological responses to climate change include altered distribution, phenology and productivity. A modelling study into the integrated effects of these various changes on fish body size suggests that averaged maximum body weight could fall by 14–24% globally by 2050. About half of the decline is accounted for by changes in distribution and abundance, with the remainder being physiological.

William W. L. Cheung
Jorge L. Sarmiento
Daniel Pauly
Research30 Sept 2012
Nature Climate Change

Volume: 3, P: 254-258
Climate change exacerbates nutrient disparities from seafood

The authors use fisheries databases and predictive models to understand past and future changes in the availability of iron, calcium omega-3 and protein from seafood. They show disproportional loss of nutrients in tropical low-income countries, which will be exacerbated by higher levels of global warming.

William W. L. Cheung
Eva Maire
Christina C. Hicks
ResearchOpen Access30 Oct 2023
Nature Climate Change

Volume: 13, P: 1242-1249
Compound climate risks threaten aquatic food system benefits

The nutritional, economic and livelihood contributions provided by aquatic food systems are threatened by climate change. Building climate resilience requires systemic interventions that reduce social vulnerabilities.

Michelle Tigchelaar
William W. L. Cheung
Max Troell
Research15 Sept 2021
Nature Food

Volume: 2, P: 673-682
Enabling conditions for an equitable and sustainable blue economy

The capacity to create an equitable and sustainable ‘blue economy’ from ocean resources will be determined by addressing social conditions, governance and infrastructure, not just resource availability, as shown by a fuzzy logic model incorporating multidisciplinary criteria.

Andrés M. Cisneros-Montemayor
Marcia Moreno-Báez
Yoshitaka Ota
Research17 Mar 2021
Nature

Volume: 591, P: 396-401
HBO1 is required for the maintenance of leukaemia stem cells

The MYST acetyltransferase HBO1 is a critical regulator in maintaining leukaemia stem cells, and a small-molecule inhibitor of HBO1 is developed that shows efficacy against a range of acute myeloid leukaemia cells.

Laura MacPherson
Juliana Anokye
Mark A. Dawson
Research11 Dec 2019
Nature

Volume: 577, P: 266-270
A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998–2013

Peng Wu
Anne M. Presanis
Benjamin J. Cowling
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-7
Winners and losers in a world where the high seas is closed to fishing

U. Rashid Sumaila
Vicky W. Y. Lam
Daniel Pauly
ResearchOpen Access12 Feb 2015
Scientific Reports

Volume: 5, P: 1-6
Reconstructing antibody dynamics to estimate the risk of influenza virus infection

Serological classification of influenza infection has classically been based on a four-fold or higher increase in antibody levels, but this approach may not be optimal. Here, the authors develop a Bayesian model to improve identification of infections in serological samples by accounting for individual antibody dynamics.

Tim K. Tsang
Ranawaka A. P. M. Perera
Simon Cauchemez
ResearchOpen Access23 Mar 2022
Nature Communications

Volume: 13, P: 1-8
Projected change in global fisheries revenues under climate change

Vicky W. Y. Lam
William W. L. Cheung
U. Rashid Sumaila
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Unequal competition: the fate of domestic fisheries facing distant water fishing in the Southwestern Atlantic Ocean

Adriana Rosa Carvalho
Sebastian Villasante
U. Rashid Sumaila
ResearchOpen Access09 Jul 2025
npj Ocean Sustainability

Volume: 4, P: 1-10
Climate change, tropical fisheries and prospects for sustainable development

Stressors arising from anthropogenic climate change threaten tropical fisheries and, in turn, those extratropical nations reliant on them. This Review discusses the impact of climate change on tropical fish stocks and catch potential, the corresponding telecoupling and subsequent adaptation measures.

Vicky W. Y. Lam
Edward H. Allison
U. Rashid Sumaila
Reviews04 Aug 2020
Nature Reviews Earth & Environment

Volume: 1, P: 440-454
Climate change impacts on the biophysics and economics of world fisheries

Global marine fisheries research shows how climate change is likely to impact the economics of world fisheries by affecting primary productivity, distribution and the potential yield of exploited species. Despite the gaps in understanding climate change effects on fisheries, the available information highlights the need for mitigation and adapation policies to minimize impacts.

U. Rashid Sumaila
William W. L. Cheung
Samuel Herrick
Reviews20 Nov 2011
Nature Climate Change

Volume: 1, P: 449-456
Correlation of Cytochrome P450 (CYP) 1A2 Activity Using Caffeine Phenotyping and Olanzapine Disposition in Healthy Volunteers

Kara Lee Shirley
Yuen Y Hon
Michael W Jann
Research04 Dec 2002
Neuropsychopharmacology

Volume: 28, P: 961-966
Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children

Tim K. Tsang
Can Wang
Dennis K. M. Ip
ResearchOpen Access20 Feb 2023
npj Vaccines

Volume: 8, P: 1-5

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