Using cryo-electron microscopy, the authors obtained structures of Streptococcus pneumoniae nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in different states. Combined with site-directed mutagenesis and biochemical assays, the structures shed light on the activity and regulation of NADPH oxidases.
- Victor R. A. Dubach
- Pablo San Segundo-Acosta
- Bonnie J. Murphy
