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Showing 1–7 of 7 results
Advanced filters: Author: Victoria A. Meliopoulos Clear advanced filters

  • Ferrets are the main animal model used for research on influenza transmission. Here, the authors investigate the dynamics of infection and transmission in ferrets using a replication-competent influenza reporter virus and real-time bioluminescence imaging.

    • Erik A. Karlsson
    • Victoria A. Meliopoulos
    • Stacey Schultz-Cherry
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track viral diversity as infection spreads to the lower respiratory tract and conclude that narrow population bottlenecks are an important feature of the within-host infection dynamics.

    • Katherine A. Amato
    • Luis A. Haddock III
    • Andrew Mehle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.

    • Avishekh Gautam
    • David F. Boyd
    • Siddharth Balachandran
    Research
    Nature
    Volume: 628, P: 835-843

  • In this Review, Schultz-Cherry, Thomas and colleagues discuss the pathogenesis of influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human respiratory tract, the contribution of the host response to severe disease, epithelial repair mechanisms following infection, and current and potential future therapies for influenza virus and SARS-CoV-2 infections.

    • Tim Flerlage
    • David F. Boyd
    • Stacey Schultz-Cherry
    Reviews
    Nature Reviews Microbiology
    Volume: 19, P: 425-441

  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652