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Showing 1–7 of 7 results
Advanced filters: Author: Victoria A. Rafalski Clear advanced filters

  • Merlini, Rafalski et al. show that dynamic microglial brain surveillance prevents hyperexcitability and seizures by Gi-dependent microglia–neuron interactions in response to evoked neuronal activity to maintain physiological network synchronization.

    • Mario Merlini
    • Victoria A. Rafalski
    • Katerina Akassoglou
    Research
    Nature Neuroscience
    Volume: 24, P: 19-23

  • Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.

    • Jae Kyu Ryu
    • Victoria A. Rafalski
    • Katerina Akassoglou
    Research
    Nature Immunology
    Volume: 19, P: 1212-1223

  • Oxidative stress can promote neurodegeneration. Akassoglou and colleagues describe Tox-seq, a functional single-cell RNA sequencing method to identify oxidative stress transcriptional signatures in CNS-resident cells. Tox-seq identified coagulation and glutathione-redox pathway genes that are coupled to oxidative stress and that could be targeted by the glutathione-regulating small molecule acivicin.

    • Andrew S. Mendiola
    • Jae Kyu Ryu
    • Katerina Akassoglou
    Research
    Nature Immunology
    Volume: 21, P: 513-524

  • Oligodendrocytes produce myelin in the central nervous system and can regenerate in adults. Brunet and colleagues show that inactivation of SIRT1 deacetylase increases the proliferation of oligodendrocyte progenitors partly by shifting other neural stem cells to this fate. Using genome-wide approaches, they delineate PDGFRα as a critical target of SIRT1 in its negative effects on oligodendrocyte lineage.

    • Victoria A. Rafalski
    • Peggy P. Ho
    • Anne Brunet
    Research
    Nature Cell Biology
    Volume: 15, P: 614-624

  • The authors show that changes in nuclear dynamics of p75NTR by γ-secretase cleavage are a novel molecular switch that determines TGF-β signaling in astrocytes. Cleaved p75NTR acts as a component of the nuclear pore complex, regulating nuclear import of Smad-2 in astrocytes. The authors find that p75NTR is required in mice for TGF-β-induced glial scar formation and reduced neuronal activity.

    • Christian Schachtrup
    • Jae Kyu Ryu
    • Katerina Akassoglou
    Research
    Nature Neuroscience
    Volume: 18, P: 1077-1080