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Showing 1–8 of 8 results
Advanced filters: Author: Victoria Madigan Clear advanced filters

  • Carbon isotopic analysis reveals global biogeographic traits in shark trophic interactions, and sheds light on the diverse foraging behaviour of sharks.

    • Christopher S. Bird
    • Ana Veríssimo
    • Clive N. Trueman
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 299-305

  • In geographic atrophy, a type of macular degeneration, retinal pigmented epithelium (RPE) cells die. This paper finds that DICER1, which processes miRNA precursors, is reduced in RPE from individuals with geographic atrophy. Cell death is not due to loss of miRNA processing, however; rather, the absence of DICER1 allows accumulation of pathological Alu repeat sequence RNAs. This work reveals a novel function of Dicer in degrading Alu RNAs.

    • Hiroki Kaneko
    • Sami Dridi
    • Jayakrishna Ambati
    Research
    Nature
    Volume: 471, P: 325-330

  • Compact Cas13 proteins are used to design RNA editors that fit into a single adeno-associated virus.

    • Soumya Kannan
    • Han Altae-Tran
    • Feng Zhang
    Research
    Nature Biotechnology
    Volume: 40, P: 194-197

  • CRISPR-based genome editing has the potential to treat many human genetic diseases, but achieving stable, efficient and safe in vivo delivery remains a challenge. This Review assesses current delivery systems for genome editors—focusing on adeno-associated viruses and lipid nanoparticles—and highlights data from recent clinical trials. Emerging delivery systems and ongoing challenges in the field are discussed.

    • Victoria Madigan
    • Feng Zhang
    • James E. Dahlman
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 875-894