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Impact of local therapy in metastatic renal cell carcinoma during medical treatment in a retrospective analysis

Sena Hoffer
Hendrik Eggers
Philipp Ivanyi
ResearchOpen Access30 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Hanna Pettersson
Behdad Zarnegar
Klas Kullander
ResearchOpen Access24 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation

Livia Demkova
Viktor Bugajev
Ivana Halova
ResearchOpen Access14 Jun 2023
Scientific Reports

Volume: 13, P: 1-15
The effect of chemotherapy regimens in male germ cell tumors on the development of primary hypogonadism

Analena Handke
Marla Geller-von Bargen
Lukas Püllen
ResearchOpen Access15 Nov 2024
Scientific Reports

Volume: 14, P: 1-8
Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence

Keyl et al. present an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, identified key prognostic marker interactions, and confirmed these in an external lung cancer cohort.

Julius Keyl
Philipp Keyl
Jens Kleesiek
ResearchOpen Access30 Jan 2025
Nature Cancer

Volume: 6, P: 307-322
Adding cetuximab to paclitaxel and carboplatin for first-line treatment of carcinoma of unknown primary (CUP): results of the Phase 2 AIO trial PACET-CUP

Gunnar Folprecht
Karolin Trautmann
Alwin Krämer
ResearchOpen Access25 Nov 2020
British Journal of Cancer

Volume: 124, P: 721-727
An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma

In this Expert Consensus, Grünwald et al. summarize their recommendations for the diagnosis and treatment of patients with renal cell carcinoma and metastasis to the bone. They also outline current challenges and unmet patient needs that should be addressed in the future.

Viktor Grünwald
Berit Eberhardt
Michael Staehler
ReviewsOpen Access14 Jun 2018
Nature Reviews Urology

Volume: 15, P: 511-521
The role of nephrectomy in metastatic renal cell carcinoma

Cytoreductive nephrectomy is the current treatment paradigm for metastatic renal cell carcinoma (RCC). However, the introduction of targeted therapies has dramatically changed the treatment landscape and may limit the role of nephrectomy in this disease. The recent CARMENA trial supports initial medical treatment of patients with RCC and synchronous metastases.

Viktor Grünwald
Axel Bex
News & Views04 Jul 2018
Nature Reviews Nephrology

Volume: 14, P: 601-602
Treatment of everolimus-resistant metastatic renal cell carcinoma with VEGF-targeted therapies

V Grünwald
C Seidel
S Weikert
ResearchOpen Access27 Oct 2011
British Journal of Cancer

Volume: 105, P: 1635-1639
Efficacy of immune checkpoint inhibitor therapy for advanced urothelial carcinoma in real-life clinical practice: results of a multicentric, retrospective study

Melinda Váradi
Orsolya Horváth
Tibor Szarvas
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Immune-related hepatic adverse events in renal cell carcinoma patients treated with immune checkpoint inhibitors: a retrospective study

Amer Saleh
Viktor Grünwald
Christopher Darr
ResearchOpen Access16 Sept 2025
BJC Reports

Volume: 3, P: 1-10
The spleen microenvironment influences disease transformation in a mouse model of KIT^D816V-dependent myeloproliferative neoplasm

Natalie Pelusi
Maike Kosanke
Hubert Schorle
ResearchOpen Access27 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

The PLK4 kinase and centrosomal protein HsSAS-6 both regulate centrosome duplication. PLK4 negatively controls an FBXW5-containing ubiquitin ligase, which targets SAS-6 for destruction to restrict centrosome re-duplication.

Anja Puklowski
Yahya Homsi
Nisar P. Malek
Research03 Jul 2011
Nature Cell Biology

Volume: 13, P: 1004-1009
Author Correction: Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Johannes Uhlig
Annemarie Uhlig
Hyun S. Kim
Amendments and CorrectionsOpen Access24 May 2024
Scientific Reports

Volume: 14, P: 1
Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer

Metastatic urothelial cancer exhibits substantial molecular heterogeneity compared with the primary tumour, complicating the development of accurate biomarkers. Pre-treatment metastatic biopsies capture real-time tumour biology and can enhance response predictions for targeted therapies, improving patient selection for precision oncology.

Niklas Klümper
Alexander Cox
Markus Eckstein
Reviews29 Oct 2024
Nature Reviews Urology

Volume: 22, P: 256-267
Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Johannes Uhlig
Annemarie Uhlig
Hyun S. Kim
ResearchOpen Access02 May 2024
Scientific Reports

Volume: 14, P: 1-11
Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events

Viktor Grünwald
Martin H. Voss
Eric Jonasch
ReviewsOpen Access26 Jun 2020
British Journal of Cancer

Volume: 123, P: 898-904
Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients—a systematic review and meta-analysis

Tamás Fazekas
Ádám D. Széles
Tibor Szarvas
ReviewsOpen Access12 Dec 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 665-672

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Impact of local therapy in metastatic renal cell carcinoma during medical treatment in a retrospective analysis

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation

The effect of chemotherapy regimens in male germ cell tumors on the development of primary hypogonadism

Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence

Adding cetuximab to paclitaxel and carboplatin for first-line treatment of carcinoma of unknown primary (CUP): results of the Phase 2 AIO trial PACET-CUP

An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma

The role of nephrectomy in metastatic renal cell carcinoma

Treatment of everolimus-resistant metastatic renal cell carcinoma with VEGF-targeted therapies

Efficacy of immune checkpoint inhibitor therapy for advanced urothelial carcinoma in real-life clinical practice: results of a multicentric, retrospective study

Immune-related hepatic adverse events in renal cell carcinoma patients treated with immune checkpoint inhibitors: a retrospective study

The spleen microenvironment influences disease transformation in a mouse model of KIT^D816V-dependent myeloproliferative neoplasm

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

Author Correction: Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer

Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events

Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients—a systematic review and meta-analysis

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