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Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes

Systematic comparative analysis across three cancer types reveals how epigenetic drugs derepress transposable elements via distinct mechanisms influenced by p53 status, offering insights for strategic use of epigenetic therapies in different cancers.

Divyesh Patel
Ville Tiusanen
Biswajyoti Sahu
ResearchOpen Access03 Jul 2025
Communications Biology

Volume: 8, P: 1-18

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Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes

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