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Showing 1–4 of 4 results

Advanced filters: Author: Vinaya Gunasri Clear advanced filters

Epigenetically driven and early immune evasion in colorectal cancer evolution

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Eszter Lakatos
Vinaya Gunasri
Trevor A. Graham
ResearchOpen Access05 Nov 2025
Nature Genetics

Volume: 57, P: 3039-3049
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment composition independent of changes in clonal composition.

Melissa Barroux
Jacob Househam
Trevor A. Graham
ResearchOpen Access14 May 2025
Nature Cancer

Volume: 6, P: 820-837
The co-evolution of the genome and epigenome in colorectal cancer

A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

Timon Heide
Jacob Househam
Andrea Sottoriva
ResearchOpen Access26 Oct 2022
Nature

Volume: 611, P: 733-743
Phenotypic plasticity and genetic control in colorectal cancer evolution

Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

Jacob Househam
Timon Heide
Trevor A. Graham
ResearchOpen Access26 Oct 2022
Nature

Volume: 611, P: 744-753