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Showing 1–6 of 6 results
Advanced filters: Author: Vincent Bondet Clear advanced filters

  • The interferon response has been shown to be linked to severity of SARS-CoV-2 infection and is an essential component of the immune response to COVID-19. Here the authors stratify patients according to COVID-19 severity and asses the interferon response showing defective responses in severe infection and highlight the importance of assay variables and confounding factors that impact the detection of interferon.

    • Nikaïa Smith
    • Céline Possémé
    • Darragh Duffy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Mucosal surfaces of the respiratory tract are the first sites of entry and defense against SARS-CoV-2. Di Santo and colleagues perform paired analysis of the nasopharyngeal and systemic immune responses of SARS-CoV-2-infected patients and demonstrate distinct compartmentalization of immunity and shifts in the microbiome.

    • Nikaïa Smith
    • Pedro Goncalves
    • James P. Di Santo
    ResearchOpen Access
    Nature Immunology
    Volume: 22, P: 1428-1439

  • Population differences in immune responses to SARS-CoV-2 can be explained by environmental exposures, but also by local adaptation acting through genetic variants acquired after admixture with archaic hominin forms.

    • Yann Aquino
    • Aurélie Bisiaux
    • Lluis Quintana-Murci
    ResearchOpen Access
    Nature
    Volume: 621, P: 120-128

  • Eosinophils have been described mainly in allergy settings but are increasingly appreciated as being involved in other aspects of immunity. Albert and colleagues use a clinically approved inhibitor of the dipeptidyl peptidase DPP4 to facilitate the recruitment of eosinophils to mouse tumors, where they are essential in tumor destruction.

    • Clémence Hollande
    • Jeremy Boussier
    • Matthew L. Albert
    Research
    Nature Immunology
    Volume: 20, P: 257-264

  • Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling.

    • Mathieu P. Rodero
    • Alessandra Tesser
    • Yanick J. Crow
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15