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Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences

Phosphorothioate (PT) DNA modifications are widespread in bacteria and play a critical role in cell physiology. Here, the authors develop two sequence-based technologies to map PT modifications across bacterial genomes.

Bo Cao
Chao Chen
Peter C. Dedon
Research05 Jun 2014
Nature Communications

Volume: 5, P: 1-13
The dynamics of hematopoiesis over the human lifespan

This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

Hojun Li
Parker Côté
R. Grant Rowe
Research05 Dec 2024
Nature Methods

Volume: 22, P: 422-434
Single-cell transcriptomic profiling of the aging mouse brain

A single-cell transcriptomic atlas of the aging mouse brain reveals coordinated and cell-type-specific aging signatures across multiple cell populations. Catalogs of aging-related genes, pathways and ligand–receptor interactions are reported.

Methodios Ximerakis
Scott L. Lipnick
Lee L. Rubin
Research24 Sept 2019
Nature Neuroscience

Volume: 22, P: 1696-1708