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Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation

Marta Llovera
Caroline Pichard
Vincent Goffin
Research28 Sept 2000
Oncogene

Volume: 19, P: 4695-4705
Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

Jeanne Tie
Yuxuan Wang
Petr Kavan
Research20 Oct 2025
Nature Medicine

Volume: 31, P: 4291-4300
Prolactin regulation of the prostate gland: a female player in a male game

Although prolactin's action on the mammary gland is well known, it is also found in the circulation of males and its receptor (PRLR) is expressed in the prostate. Furthermore, studies have supported the contribution of the canonical PRLR-Jak2-Stat5a/b pathway to prostate cancer tumorigenesis and progression. In this Review, the authors discuss the data regarding the role of prolactin in the prostate and consider the therapeutic potential of targeting prolactin signaling pathways in the treatment of advanced prostate cancer.

Vincent Goffin
David T. Hoang
Marja T. Nevalainen
Reviews04 Oct 2011
Nature Reviews Urology

Volume: 8, P: 597-607
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone

Christine Dos Santos
Laurent Essioux
Pierre Bougnères
Research20 Jun 2004
Nature Genetics

Volume: 36, P: 720-724
Drug Insight: prolactin-receptor antagonists, a novel approach to treatment of unresolved systemic and local hyperprolactinemia?

Excess local tissue production of prolactin may be associated with development and progression of breast and prostate cancers. Pure prolactin-receptor antagonists, such as described here, block prolactin signaling, and may provide a novel therapeutic approach to these cancers, as well as a means of treating drug-resistant forms of hyperprolactinemia.

Vincent Goffin
Philippe Touraine
Paul A Kelly
Reviews01 Oct 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 571-581
STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway

Laura Cheradame
Ida Chiara Guerrera
Vincent Goffin
Research08 Oct 2021
Oncogene

Volume: 40, P: 6627-6640
Do dietary calcium and vitamin D matter in men with prostate cancer?

Active surveillance protocols rely on the premise that low-risk disease remains indolent. Thus, understanding environmental factors that promote the progression of indolent disease towards aggressive stages is important to manage men on these programmes. In this Perspectives, the authors describe the data regarding the roles of dietary calcium and vitamin D in prostate cancer and consider whether intake should be modified in men with the disease.

Thierry Capiod
Nicolas Barry Delongchamps
Vincent Goffin
Reviews15 May 2018
Nature Reviews Urology

Volume: 15, P: 453-461
Prostate luminal progenitor cells: from mouse to human, from health to disease

In this Review, Baures et al. discuss prostate luminal progenitor cells, covering their functional properties and potential role in prostate pathology. In addition, the authors describe different approaches to classifying these cells, and unify multiple identifiers that have been used to define prostate luminal progenitor cells.

Manon Baures
Charles Dariane
Vincent Goffin
Reviews25 Jan 2022
Nature Reviews Urology

Volume: 19, P: 201-218
Author Correction: Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation

Tristan J. M. Gonçalves
Florence Boutillon
Anne-Sophie Armand
Amendments and CorrectionsOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1
mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions

Emma Cosialls
Emeline Pacreau
Ahmed Hamaï
ResearchOpen Access15 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-14
A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers

Saegerman et al. perform saliva SARS-CoV-2 testing in a cohort of nursing home workers in Belgium who are either unvaccinated or have received one or two doses of the BNT162b2 mRNA vaccine. The authors show that vaccination protects against shedding of SARS-CoV-2 into saliva and observe greater variability in viral load in the unvaccinated group.

Claude Saegerman
Anh Nguyet Diep
Laurent Gillet
ResearchOpen Access10 Jan 2022
Communications Medicine

Volume: 2, P: 1-11
Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation

Tristan J. M. Gonçalves
Florence Boutillon
Anne-Sophie Armand
ResearchOpen Access10 Apr 2019
Scientific Reports

Volume: 9, P: 1-12
Prolactin and its receptor as therapeutic targets in glioblastoma multiforme

Antonela Sofía Asad
Alejandro Javier Nicola Candia
Marianela Candolfi
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-16

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