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Showing 1–3 of 3 results
Advanced filters: Author: Vipin A. Rangari Clear advanced filters

  • A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.

    • Vipin Ashok Rangari
    • Evan S. O’Brien
    • Susruta Majumdar
    Research
    Nature
    Volume: 640, P: 265-273

  • A newly discovered negative allosteric modulator of the µ-opioid receptor works together with naloxone to potently block opioid agonist signalling with reduced adverse effects.

    • Evan S. O’Brien
    • Vipin Ashok Rangari
    • Brian K. Kobilka
    Research
    Nature
    Volume: 631, P: 686-693

  • Active-state structures of the κ-opioid receptor in complexes with the G-protein heterotrimers Gi1, GoA, Gz and Gg provide insights into the actions of hallucinogenic opioids and G-protein-coupling specificity at the κ-opioid receptor.

    • Jianming Han
    • Jingying Zhang
    • Tao Che
    ResearchOpen Access
    Nature
    Volume: 617, P: 417-425