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Showing 1–5 of 5 results

Advanced filters: Author: Virginia Plá Clear advanced filters

A curious concept of CNS clearance

Virginia Plá
Erik Kroesbergen
Maiken Nedergaard
Research11 Mar 2025
Nature Neuroscience

Volume: 28, P: 731-733
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage

Cervical lymphatics drain cerebrospinal fluid and clear metabolic waste from the brain. Du et al. show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with prostaglandin F_2α rescues brain clearance.

Ting Du
Aditya Raghunandan
Douglas H. Kelley
Research15 Aug 2024
Nature Aging

Volume: 4, P: 1418-1431
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

Acute oedema after traumatic brain injury is accompanied by the suppression of glymphatic and lymphatic fluid flow due to excessive systemic release of noradrenaline.

Rashad Hussain
Jeffrey Tithof
Maiken Nedergaard
Research15 Nov 2023
Nature

Volume: 623, P: 992-1000
An unnoticed player overseeing CSF flux

A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance.

Virginia Plá
Maiken Nedergaard
News & Views02 Dec 2022
Nature Cardiovascular Research

Volume: 1, P: 1114-1115
Circadian control of brain glymphatic and lymphatic fluid flow

Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.

Lauren M. Hablitz
Virginia Plá
Maiken Nedergaard
ResearchOpen Access02 Sept 2020
Nature Communications

Volume: 11, P: 1-11